There are plenty of good ways to deal with creatures, so as long as you save them for the right targets, it is mostly about small edges, synergy, using your cards at the right time, a timely combat trick or double-block, and executing your archetypes game plan correctly
Exiling four cards off the bat means that youll nab about 1.5 lands on average, but if your opponent happened to delve any lands away or theyve otherwise ended up exiled, perhaps through other Eldrazi effects like Ingest, then youre getting great bang for your buck
Both Jeskas Will and Culling Ritual are big players in both cEDH and stronger EDH tables, and offer unparalleled resources that are format-contingent
Manic Scribe lets you mill each opponent for three each turn if you have delirium, which should be easy to enable with mill cards like Mesmeric Orb
And I run Species Specialist in almost creatureless decks
Blue: Black: Red: Shivan Dragon (Shout out to Dragon Whelp and Nalathni Dragon) Green: None, not even Cockatrice Gold: The Elder Dragon cycle Those are the only flyers prints up through 1995 that can kill a 5-toughness flying defender