Each color produced format-defining leaders in different eras
A card like Lich's Mastery specifically states that you cant lose the game. That means you wont lose the game for having 0 life or no cards in your library to draw from
Orcish Bowmaster, Hullbreacher, Sheoldred, and Narset, Parter of Veils all make symmetrical card draw far less symmetrical
If you can pump your armies up to 4/4s or greater or copy the Gorgoroth, the Army keeps replacing itself when it dies, resulting in infinite death trigger/infinite ETB combos
But making a popular Timmy blue rare or popular Johnny white rare is much more of a challenge
Nexus of Fate was not only mythic rare, but also an incredibly powerful Timewalk effect that would go on to warp several formats before being banned in Pioneer and in formats across MTG Arena