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Activation of initiators like caspase-9 and caspase 8 in the intrinsic or extrinsic pathways, respectively, promotes the activation of executioner caspases and pro-apoptotic pathways causing DNA injury and apoptosis (Calopa et al
Nanomedicine platforms can be designed to selectively target MDSCs based on their surface receptor expression or metabolic vulnerabilities, thereby reducing systemic immunosuppression while preserving beneficial myeloid populations (32, 33)
11 years of research and development, a total of 19 Chinese invention patents and 2 international invention patents have been declared, of which 7 Chinese invention patents and 8 software copyrights have been authorized
As you can see, theres a clear trade-off
doi: 10.1007/s12032-024-02454-x 82
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