A randomized, double-blind, placebo-controlled study used topical oxidized glutathione (GSSG) 2% lotion applied twice daily for 10 weeks in 30 women
Individuals with greater body shape concerns and dissatisfaction with their body image, higher levels of anxiety and depression, and poorer organizational skills are more likely to discontinue treatment
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Here is a short list of problems that could be related: obesity diabetes fatigue any psychiatric or neurological problem, difficulty sleeping, muscle tension, or excessive startling any issues with allergies or histamine nausea and vomiting, including but not limited to pregnancy hangriness that is not verifiably due to low blood sugar and resolved by stabilizing blood sugar diarrhea, excessive gastrointestinal transit time heart palpitations, twitches and spasms, chronic pain, tremors high estrogen, low testosterone, any problems that appear as high estrogen or low testosterone but are not accompanied by the expected changes in those hormones petechiae, purpura, cancer, anything resembling hypoxia such as blue hands and feet upon standing any sulfur-related odors such as rotten eggs or matches any form of intolerance to any dietary or supplemental component that contains sulfur anywhere in its structure, like thiamin or lipoic acid or any intolerance to any of the following: fasting, fasting-mimicking diets, ketogenic diets, any kind of catabolic state, B6, calcium, riboflavin, or CoQ10

Taal and Selby, 2025)
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