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Pham LV, Schwartz AR
While 2.5 mg may produce initial appetite suppression and modest weight loss, clinical data shows this dose provides suboptimal long term efficacy
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The metric used to quantify in vitro drug synergy is given by the log 2 ratio of the additive LD50 (computed from the two single agent responses as described above) and the combination LD50 for each cell line
Risk ratios (RRs) and hazard ratios (HRs) with 95% confidence intervals (CIs) compare tirzepatide with lifestyle intervention (reference)
The 4-week minimum at each dose level is not arbitrary
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