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Tirzepatide, which activates both GLP-1 and GIP receptors, engages a broader signaling cascade and may produce more pronounced gastrointestinal effects in genetically sensitive individuals

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Pruritus (itching) Generalized itching without visible skin changes is reported by some retatrutide users

Nausea is the most common side effect and is usually manageable with dietary adjustments such as eating smaller meals, avoiding high-fat foods, and eating slowly

Science 224 , 569573 (1984)