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Because CagriSema pairs two different hormone pathways in one injection, researchers describe it as a dual agonist rather than a pure GLP-1

The phase 3 TRIUMPH-4 trial extended to 68 weeks and showed continued weight loss throughout, suggesting that longer maintenance periods produce better outcomes

These developments underscore the expanding arsenal of diabetes drugs available to clinicians

Both Rybelsus and Januvia enhance incretin hormone activity, but through different mechanisms: Rybelsus directly activates GLP-1 receptors to stimulate insulin secretion when blood glucose levels are high, while Januvia works by preventing the breakdown of naturally occurring incretin hormones, thereby enhancing insulin secretion and suppressing glucagon release