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This failure is largely due to testing exclusively on cancer cell lines grown in liquid medium, a condition that predicts in vivo efficacy to anticancer drugs worse than cell culture in 3D gels [4, 5] and is far from adequately reflecting the therapeutic responsiveness of cancers within their native microenvironment [2, 3]

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Meeting highlights PRAC 2326 October 2023 GLP-1 receptor agonists: available evidence not supporting link with thyroid cancer

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however, no dose adjustments are needed based on renal function