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Prednisolone increases appetite and may cause weight gain, potentially counteracting Wegovy's weight loss effects
Furthermore, recent investigations reported that empaglifozin is able to restore ion hemostasis in failing cardiac myocytes, reducing intracellular sodium overload by the inhibition of the sarcolemmal Na+/H+ exchanger (Packer, 2019)
Tirzepatide became the answer
PMID: 12 LincoffAMBrown-FrandsenKColhounHMDeanfieldJEmersonSSEsbjergSet al
Available at: NCBI
Patients who understand that the re-titration period is a necessary pharmacological bridge, not a step backward, are more likely to persist through the 12 weeks it takes to reach a therapeutic tirzepatide dose
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