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The clinical improvement was assessed by using Z test to identify significance of mean difference of VAS score and its percentage on both cheeks with the assumption that the distribution of the collected VAS scores is normal
Approximately equal numbers of patients were randomized to receive placebo, 100 mg of sitagliptin once daily, 500 mg or 1000 mg of metformin HCl twice daily, or 50 mg of sitagliptin twice daily in combination with 500 mg or 1000 mg of metformin HCl twice daily
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Doses start very low (0.25 mg weekly for semaglutide) and titrate up slowly
60% of patients report insufficient nutritional guidance, affecting treatment efficacy
