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Statistical analyses were performed using GraphPad Prism software
In general, the rate of synthesis, regeneration, and recycling of glutathione is determined by three key factors 2 : Cellular levels of cysteineCysteine availability is the rate-limiting step in glutathione production, so not enough cysteine and de novo synthesis of glutathione will slow Enzyme glutamate cysteine ligase (GCL) activity, in part regulated by glutathione feedback inhibition Glutathione depletion due to high levels of oxidative stress, inflammation, or exposure to xenobioticsin these situations, de novo synthesis is upregulated Of course, as an antioxidant, one of the most important roles of glutathione is shielding cells from reactive oxygen species and reactive nitrogen species, but thats not its only job
Glutathione is often referred to as the bodys master antioxidant due to its central role in neutralising oxidative stress and supporting normal detox processes
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This is one of the key mechanisms through which psoriasis initiates and sustains itself
24 Dietary Antioxidants Vitamins and Minerals Fruits and vegetables contain antioxidant vitamins, including vitamin C, vitamin E, and pro-vitamin A carotenoids, activities of which have been well-studied
