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doi: 10.1111/1750-3841.16519 149

In mice, the bulk of the metabolic improvement seen upon FGF21 treatment derives from centrally mediated weight loss, whereas FGF21 analogs elicit limited weight loss in humans

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Nevertheless, available evidence indicates that prolonged exposure to supraphysiological doses of AAS is associated with a substantial risk of adverse psychological outcomes, including the development of dependence and persistent emotional and interpersonal difficulties (62)

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