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An MJFF-funded Phase IIb placebo-controlled trial did show mild benefit but because the placebo group also improved, the significance of these results is unclear

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To overcome these limitations, the researchers designed and synthesized novel small molecules with improved metabolic stability, BBB penetrability, and oral activity

impaired cholinergic transmission is the hallmark of Alzheimers disease [34, 35]

Severe sleep disruption (fewer than 4 hours per night)