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If labs trend high or hematocrit rises, weekly dosage can be reduced promptly

Internal factors include the increasing need for glutathione as an important part of various processes in our bodies, such as food for our immune system, recycling of vitamin C, vitamin E and alpha lipoic acid, repairing our DNA, and protecting our cells from oxidative stress to name just a few

Alterations of Vascular Thromboresistance The pioneer work of Harker et al (1976) suggests that endothelial cell injury associated with reduced platelet survival is involved in the initiation of vascular disorders induced by experimental hyperhomocysteinemia

Conclusions and Outlook Despite uninspiring outcomes in clinical trials of the first wave of potential NASH therapies, a spate of promising mid-to-late stage clinical trials has provided a needed morale boost to NASH patients, endocrinologists and hepatologists, and caregivers

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Contribution statement All authors were responsible for drafting the article and revising it critically for important intellectual content