Priority research needs include large-scale randomized controlled trials to establish efficacy and safety, dose-ranging studies to optimize treatment protocols, long-term safety studies particularly regarding cancer risk, and comparative effectiveness research with established therapies
Concurrent nutritional deficienciesparticularly folate or iron deficiencycan impair the response to B12 treatment, as these nutrients work together in red blood cell production
The authors declare no competing interests
Hidalgo for assistance with ICP-MS experiments
But, as mentioned, those studies were much too small to really know whether it is safe
Over time, the nervous system may become more sensitive, so attacks become longer, more frequent, or are replaced by constant burning pain