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Crespel, A., De Boisvilliers, F., Gros, L
Cagrilintide is a long-acting amylin analogue administered once weekly by subcutaneous injection, reducing appetite by slowing gastric emptying and suppressing glucagon
As of 2026, two oral GLP-1 medications are FDA-approved for weight loss: the once-daily Wegovy pill (oral semaglutide 25 mg) and orforglipron (Foundayo)
Here, each regional effect is summarized
DSIP readily crosses the blood-brain barrier to exert central effects and may enhance inhibitory neuronal activity or modulate sleep-regulating brain regions
Clinical trials show GLP-1 agonists produce significantly greater weight losstypically 1522% of body weight over 68 weekscompared to phentermine's effects
