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Over-the-counter stool softeners like docusate are safe to use with GLP-1 therapy and can prevent discomfort without counteracting the medication's effects
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Diabetes 55: S70-S77, 2006
The combination carries low hypoglycaemia risk when used alone, but gastrointestinal side effects (nausea, vomiting, diarrhoea) are common and may be more pronounced initially
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Interestingly, inhibition of NLRP3 inflammasome activation reversed the M1 polarization of TMAO-stimulated macrophages, suggesting that NLRP3 plays a crucial role as a proteolytic activator in TMAO-induced macrophage responses
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