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The funder was responsible for the study design and contributed to data collection, analysis and interpretation and participated in the preparation and review of the manuscript in collaboration with the authors

Key points GLP-1 is a hormone that increases insulin release and prevents the release of too much glucagon, helping manage blood glucose levels in individuals with type 2 diabetes GLP-1 receptor agonists, such as liraglutide and semaglutide, effectively reduce blood glucose levels Semaglutide is more effective than liraglutide at reducing blood sugar levels Tirzepatide is a newer GLP-1 receptor agonist that also mimics the actions of another hormone called GIP, which can also reduce blood sugar levels A randomised controlled trial showed that tirzepatide led to more significant blood sugar reductions than semaglutide across three doses Tirzepatide may be more effective than semaglutide at higher doses, but this needs further investigation Liraglutide and semaglutide are available in the UK and the US, while tirzepatide is only available in the US but is likely to be approved in the UK soon

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The authors noted that delayed gastric emptying and reduced thirst may require more active treatment with bulk-forming laxatives like psyllium, stool softeners such as docusate sodium, or osmotic or stimulant laxatives like polyethylene glycol

Many commercial plans cover semaglutide for type 2 diabetes