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Patient education priorities: Healthcare providers should emphasize that while occasional timing adjustments may be necessary, the FDA guidance requires maintaining at least 72 hours between doses for any schedule change

Nevertheless, although the number of patients who had a TyG index value of 8.8 (non-insulin resistance) increased significantly in both the no/low CKD risk and CKD groups after 12 months of treatment ( Figures 3A, B ), when further stratification according to CKD severity was performed, a lower proportion of patients achieving a TyG value 8.8 was reported in the subgroup of very high CKD risk ( Figures 3CE )

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