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Jan Paolo Dipasupil provides exactly this assessment, and the prescription decision follows from the clinical findings rather than a preference exercise

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FDA-Approved GLP-1R Obesity Medications (As of February, 2025) GLP-1 Treatments: Results, Side Effects, and Lifestyle Factors In terms of weight loss in people, GLP-1 drugs have demonstrated up to a 15-20% weight loss in individuals

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Combined use may represent a more optimal strategy (Tsuriya et al., 2025