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36 As 85% of aconitase in the brain is the mitochondrial isozyme, a decrease in brain aconitase activity is considered a sensitive indicator of excess mitochondrial superoxide production

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Anti-tumour necrosis factor treatment for the prevention of ischaemic events in patients with deficiency of adenosine deaminase 2 (DADA2)

Always escalate one compound at a time with at least a two-week stabilization period between escalations