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Under therapeutic stress, subpopulations enhance mitochondrial respiration, FAO, and TCA cycle activity, promoting redox balance and bioenergetic resilience that underpin chemoresistance and metastatic potential [108]

IL-33, an alarmin cytokine stored in nuclei, is released upon cell damage and has complex effects (can be pro-inflammatory or tissue-protective)

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NNMT converts nicotinamide, a form of vitamin B3, into 1-methylnicotinamide