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Given that obesity is a chronic and relapsing disease, it is important to understand the effectiveness of different strategies to maintain WL: TRIUMPH-6 (NCT06859268) will assess changes in bodyweight at 116 weeks in individuals with obesity who have completed 80 weeks of retatrutide, comparing continued treatment at high or low doses of retatrutide versus switching to placebo for the last 36 weeks
Animal studies have shown potential risks to fetal development, and human data remain limited
However, patients who lose 1015% of body weight on GLP-1 and then stop the medication often do not regain every pound lost
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