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Since the mean/median duration for each of these studies was 100,000 patients prescribed a GLP-1RA, after propensity matching, there was reduced risk for PDAC during a 5-year observation period for GLP-1RA users compared to six categories of commonly used diabetes medication classes 44

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In this study, participants taking orforglipron experienced an average A1C reduction of 2.1% and an average weight loss of 10.1 kilograms at 26 weeks, which was significantly greater than those in the placebo and dulaglutide groups

Our findings underscored the potential ocular benefits of SGLT2 inhibitors and GLP-1 RA drugs beyond their established metabolic effects, and they may carry meaningful clinical and public health implications, particularly for patients with type 2 diabetes at risk for cataract-related visual impairment, the researchers concluded

Researchers gave 32 men with ED a combination of intranasal PT-141 (either 7.5 or 10 mg) plus oral sildenafil (50 or 100 mg), then used a RigiScan device to objectively measure erectile rigidity over 6 hours.Impressively, adding PT-141 to sildenafil increased the duration of erectile activity by over five-fold compared to sildenafil alone