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A recent proteomic study suggested altered mitochondrial function in the cerebrovasculature isolated from deceased cognitively healthy E4 carriers compared to non-E4 carriers, indicating that cerebrovascular bioenergetics may indeed be altered in cognitively healthy E4 carriers (Ojo et al., 2021)

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The clinical effects of the medication are similar to GLP-1 RAs

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If weekly dose, consider holding the medication for one week before the surgery/procedure. Additionally, the AANA has developed a document, Anesthesia Care of the Patient on a GLP-1 Receptor Agonist, to educate its members on anesthesia care

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