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In order to prevent the patent from lapsing, the amount listed above, which includes the required maintenance fee and the late payment fee, must be paid within the one-year period of grace following the filing date anniversary, a letter from regulators said, putting the anniversary date at March 20, 2019
It is estimated that clinical trials evaluating liver-related events in patients with MASLD and compensated or decompensated cirrhosis would require a minimum recruitment of 2,886 patients with at least four years of follow-up and 1,602 patients with at least two years of follow-up, respectively
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