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Mice were placed into a stereotaxic frame and a craniotomy was performed to allow unilateral microinjection of 5 l of 30 M into the left lateral ventricle (coordinates: +1 mm M/L, 0.5 mm A/P, 2.5 mm D/V from bregma)

check the NIHR 'Be Part of Research' portal or ClinicalTrials.gov for current recruiting studies

D., Zdravkovic, M., & Moerch, U

doi:10.1111/jne.12643 20

If appetite suppression makes this difficult, consider liquid protein sources like shakes, which are generally easier to consume when appetite is low

Intriguingly, a phase 2B clinical trial of tirzepatide in people with diabetes and obesity suggested that this analogue, at the highest doses tested, has superior effects on glycaemia in comparison to the benchmark GLP-1 analogue dulaglutide (reductions in HbA1c of 1.9% vs