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The WHI study did NOT use BHRT, they used drug therapy
22 Table 4
Five smaller meals spread throughout the day prevent the stomach from ever becoming uncomfortably full
There is no evidence to suggest that the fundamental mechanisms of action differ between sexes
ACSL4 catalyzes the reaction of PUFAs to polyunsaturated fatty acid-coenzyme A (PUFA-CoA), and then the PUFA-CoA undergoes esterification by lysophosphatidylcholine acyltransferase 3 (LPCAT3) to become polyunsaturated fatty acid-phospholipids (PUFA-PLs), which are then oxidized by reactive oxygen species (ROS) to cytotoxic phospholipid hydroperoxides (PL-OOH), leading to cell death through membrane modification (Liu et al., 2025
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