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Overall Adverse Event Rates Dose Group Any Adverse Event (%) GI Adverse Events (%) Discontinuation Due to AE (%) Placebo 72.1% 32.6% 0% 1 mg 88.6% 48.6% 2.9% 4 mg (escalated) 88.6% 60.0% 5.7% 4 mg (single dose) 90.9% 63.6% 6.1% 8 mg (escalated) 87.5% 57.5% 5.0% 8 mg (single dose) 88.6% 62.9% 5.7% 12 mg (escalated) 97.2% 66.7% 8.3% Source: Jastreboff AM, Kaplan LM, Fras JP, et al
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The B12 component remains the same regardless of indication
Rapid weight loss can contribute to muscle loss, whereas a slower reduction in body fat may help preserve lean muscle mass
Zero to One by Peter Thiel Why Read It
A purity test (HPLC) measures how much of the powder is the intended compound, an identity test confirms it's the right one, and it's screened for bacterial residue
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