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These data support direct modulation of PB signaling by semaglutide-induced neuronal stimulation in the hypothalamus
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But it also leads me to wanting to say its interesting, because if that had been our motivation to actually say, oh, there's weight loss in diabetes, let's pursue it in people with obesity, I don't think we would've done that because the weight loss in people with diabetes wasn't that impressive
This once-weekly injectable demonstrated an average weight loss of 20.9% in trials, making it a suitable option for those needing significant weight reduction
They just have not reached the threshold for noticeable effects yet
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