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A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient
Its natural presence in the body contributes to its perceived safety profile
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In men, that stimulates the testes to produce testosterone and maintain sperm production
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It's particularly important if patients are above 70 years of age or have liver and kidney issues
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