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Overall, the administration of charged NPs need to be performed avoiding potential side effects related to the used NP concentration (Zhang et al., 2021a): nanocarriers with superficial cationic motifs exhibit a higher macrophage uptake and clearance by the mononuclear phagocyte system (MPS) compared to uncharged nanosystems, reducing the internalization in the targeted cells

Detailed dosage guidance and instructions are not displayed publicly for quality and safety reasons

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