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Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D, et al
in a study in patients with leukemia, plasma pentostatin concentrations determined 1 hour after administration of 0.25 or 1 mg/kg of the drug as a 30 min iv infusion averaged approximately 0.4 or 1.26 ug/ml, respectively
S.CrouseM
Therapeutics with enhanced efficacy, improved pharmacokinetics (PK) allowing less-frequent dosing and good tolerability remain in high demand to address the unmet medical need of patients with obesity
The trouble is that the marketing has run far ahead of the science, and some of the substitutes we once celebrated as harmless have recently earned some serious asterisks
Changing the reconstitution volume changes the final concentration of the solution
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