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The practical message is that a biologically plausible mechanism does not make something clinically effective, and absence of reported harm is not evidence of safety

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Importantly, all ASVs within six of the genera mapped to identical species when analyzed by both methods

(Earlier research found that a higher 4.5-mg dose of cagrilintide led to 10% weight loss after 26 weeks in adults without diabetes.) But combining the two peptides and tackling appetite hormones from different but complementary angles appears to be more effective than either peptide alone

In briefing documents for the meeting, the FDAs experts say there is a lack of evidence on effectiveness and safety to justify letting pharmacies make the peptides that the panel will review