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Elevated adiponectin concentrations have been noted in major clinical trials with GLP-1RAs (123, 188) and, more robustly, with tirzepatide (189)

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However, sudden visual loss, a new blind area or rapidly worsening eyesight requires emergency evaluation

Less common symptoms like fatigue or reduced appetite may also appear as your metabolism shifts

Once you understand why this fatigue shows up, you can usually manage it, minimize it, or prevent it altogether

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