Thymoquinone may also accumulate in certain tissues or organs, such as the liver, kidney, and lungs, depending on the route of administration and duration of exposure
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Acute measurements that will require more extensive study are needed before any meaningful conclusion can be made regarding the long-term prospects for combination therapy as mixture or for a single molecule with integrated dual agonism
In recent years, the role of GPX3 in oxidative stress has been reported, for example: GPX3 can inhibit the expression of HIF1- by regulating ROS, thereby inhibiting the growth of melanoma cells (Yi et al., 2019)