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According to the UK Summary of Product Characteristics (SmPC), the most frequently reported digestive side effects include: Nausea (very common, affecting more than 1 in 10 patients) Diarrhoea (very common) Vomiting (very common) Constipation (common) Abdominal pain or discomfort (common) Dyspepsia (indigestion) (common) Decreased appetite (very common) These effects typically occur most prominently during the initial weeks of treatment or following dose escalation, and often diminish over time as the body adapts to the medication