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The available evidence indicates quite convincingly that SSRI use may play a causal role in upper gastrointestinal bleeding and that these drugs may act synergistically with other bleeding risk-increasing medications such as NSAIDs or low-dose aspirinPatients should be informed about the likelihood of possible upper gastrointestinal bleeding and high-risk patients should be followed closely. Psychiatric Drugs and ALS A research team at the Karolinska Institute in Sweden announced a worrisome drug complication ( JAMA Network Open , June 4, 2025)