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In fact, platelet-activating factor binding to PAFr leads to the production of inositol trisphosphate (IP3) through the phosphatidylinositol cycle, which in turn binds to inositol 1,4,5-triphosphate receptor type 1 (IP3R1) to induce the release of Ca 2+ stored in the endoplasmic reticulum (Kroegel et al., 1989

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It senses fluctuations in extracellular and intracellular amino acids to modulate cellular growth, metabolism, and survival (Figure 2)

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explore the mechanism of action of cagrilintide through single-cell biology and circuit manipulations in the brain to rationalize therapy for obesity

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