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Circulation 116 (12), 14131423
By activating GLP-1 receptors, Retatrutide markedly improves insulin sensitivity, promotes satiety, and reduces caloric intake, thereby directly combating insulin resistance and hyperglycemia, core drivers of accelerated aging
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This outcome was particularly noteworthy as it highlighted the potential of semaglutide to go beyond glycemic control and weight management, offering protective benefits against serious cardiovascular outcomes
(25% of body weight), compared to 1.5% on placebo, according to data not controlled for type 1 error
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