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Govender T, Naicker T

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GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation

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HIF-1 directly interacts with HREs in the promoter regions of genes encoding glycolytic enzymes, increasing the expression of key enzymes such as M2 pyruvate kinase (PKM2) [32], aldolase A [33], enolase (ENO) [33] and lactate dehydrogenase A [33]