Starting low and gradually increasing it will help to reduce the possibility of adverse effects
Koizumi and Y
Interestingly, despite the presence of oxygen, quiescent ECs predominantly rely on glycolysis to generate approximately 85% of their ATP and bypass OXPHOS, likely due to their low mitochondrial content [25,26,27,28,29]
Oxidative damage further exacerbates mitochondrial dysfunction, increasing outer membrane permeability (MOMP) and disrupting bioenergetic homeostasis [47, 48]
The study protocol was approved by the ethics committee of Louisiana State Health Sciences Center-Animal Care Committee (Animal Care protocol number P-15-006), and all the methods were carried out following the approved guidelines
IOP Conf Ser Earth Environ Sci