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(2009) did not find significant improvement in GSH biomarkers following IV GSH therapy from baseline to week 4

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doi:10.1111/j.1472-8206.2008.00638.x, PMID: 19207541 Kumar A, Garg R (2008) Kumar P (2008) Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome

These modifications reduce binding affinity to IGF-binding proteins (IGFBPs), which is the property most often examined in comparative research