(2014) 10:e1004228
In an effort to counteract the downer effect, the brain amps up the release of dynorphin, leaving us anxious and overstimulated
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doi:10.3109/00365528709091004 Odunsi-Shiyanbade ST, Camilleri M, McKinzie S, et al
Environmental risk factors include maternal excessive alcohol consumption, smoking (the most debated), increased use of anti-inflammatory/painkillers, and endocrine-disrupting chemicals consumption (particularly diethylstilbestrol) [84,85,86,87]
Hormetic-like responses involve the simultaneous stimulation of many independent cellular functions/endpoints and define the boundaries of biological plasticity 68