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Pharmacologically, these agents avoid parenteral delivery, cold-chain logistics andunlike peptide oral semaglutidedo not require fasting or co-administration with an absorption enhancer, which may facilitate adherence and global access

Microglia activated by excessive glutamate levels can secrete various cytokines, which facilitate glutamate release presumably through xc() on microglia, and suppress the uptake of glutamate through EAATs on astrocytes [71, 88, 89]

The recommended dose of Wegovy is 2.4 mg once weekly, reached through a 16-week dose escalation schedule (0.25 mg, 0.5 mg, 1.0 mg, 1.7 mg, then 2.4 mg)

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