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Caloric restriction and nutritional changes may also play a role
McGillis ST, Fein H
Holistic support including medical monitoring, therapy, and, when appropriate, medication that targets anxiety, depression, or OCD tendencies
Endpoints frequently measured include the activity of alkaline phosphatase (ALP), an early marker of osteoblast differentiation, the expression of the master osteogenic transcription factor Runx2, and the deposition of a mineralized matrix, which can be visualized with Alizarin Red staining
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That sounds pretty harsh
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