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Research in people using GLP-1s for obesity shows: Nausea, vomiting, diarrhea and constipation are the leading side effects.Nature+1 The risk of these symptoms typically increases with dose, especially during dose escalation.Nature+1 Constipation in particular is reported more often in obesity trials than in diabetes trials.Taylor & Francis Online+1 In everyday language: your digestive system is being asked to slow down and adjust, while your eating patterns and appetite are changingsometimes dramatically and quickly

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These effects make it especially relevant for conditions involving irritation or breakdown of the intestinal barrier