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Importantly, these findings were independent of any direct action of leptin in the heart since no spillover of leptin into the circulation was detected during ICV leptin infusion (Fig

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These cytokines can promote cognitive dysfunction as they are able to disrupt the blood-brain barrier (BBB), allowing proinflammatory cytokines (52), cells (such as dendritic, B cells, and T cells) (52), and gut microbes or toxins (355) to translocate into the brain and promote inflammation ( Figure 10 )

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Healthy eating and regular exercise remain essential for long-term success

Elevated ROS levels can exacerbate mitochondrial damage, primarily manifested as irreversible ultrastructural pathological changes such as mitochondrial swelling, cristae fragmentation, and membrane rupture [45]