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Patient selection criteria are not well-established, and determining which patients are most likely to benefit from these therapies requires clinical judgment based on limited evidence
Its benefits often include: Its well tolerated and easy to incorporate into a routine
Caution is advised
Other interactions can increase side effects or make them more severe
While real-world results may be slightly less, the improvements go beyond weight: Lower blood sugar, blood pressure, and triglycerides Reduced waist circumference and sleep apnea symptoms Better health-related quality of life Fewer major cardiovascular events Reduced progression of fatty liver disease and chronic kidney diseaseeven in the absence of weight loss (Mozaffarian et al., 2025)
Coronary and arterial plaque (atherosclerosis) develops gradually as cholesterol particles such as LDL in the blood are "lipid oxidized" and damage the blood vessels' lining, forming a plaque
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