So if we were to inhibit the SLC33A1 transporter, the GSSG would accumulate, and the cancer cells would die. Our work demonstrates that defining how nutrients and metabolites are transported across cellular and organelle membranes reveals fundamental principles of cell biology while uncovering a major class of disease-relevant and therapeutically tractable proteins, Birsoy says
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Chen F, Muhammad FG, Khan ZI, Ahmad K, Malik IS, Ashfaq A, et al
Increasing Glutathione Levels to Protect the Liver Increasing Glutathione levels in the body can help protect the liver from oxidative stress and damage, with many studies supporting this